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Following single oral doses R , S -lipoic acid (racemic mixture), peak plasma concentrations of R -lipoic acid were found to be 40%-50% higher than S -lipoic acid, suggesting a differential absorption in favor of the R -enantiomer (6, 8, 11)

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Whilst B12 is water-soluble and excess is excreted through urine, the liver stores substantial reserves lasting several years

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