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First, preclinical studies indicate that GLP-1R activation can reduce excitatory synaptic input onto VTA dopamine neurons and suppress intake of highly rewarding foods (5658)
White bread, sugary cereals, candy, and sweetened beverages offer little nutritional value while potentially contributing to discomfort
However, using a product past its BUD means accepting a degree of uncertainty about potency and sterility that the pharmacy dating was designed to eliminate
The safety profile was consistent with GLP-1 class compounds
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