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The same trend was seen after the 2021 trial, known as Step 1

See our GLP-1 timeline guide for more details on what to expect

Understanding how these medications work, their results, and their safety profiles helps individuals and their healthcare provider determine the right medication to help them lose weight and reach their weight loss goals

John Horneff, an associate professor of orthopedic surgery at the University of Pennsylvania and the lead author of the study, said the potential side effects of GLP-1 drugs came to light when some patients developed serious tendon tears after relatively minor injuries

This can lead to stool becoming harder and more difficult to pass