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APE1, apurinic/apyrimidinic endonuclease 1

Ozempic is not FDA-approved for weight loss, but other GLP-1 medications such as Wegovy, which also contains semaglutide, and Foundayo (orforglipron) are FDA approved for weight management

Beyond the rapid clearance by the reticuloendothelial system (RES) which reduces bioavailability, the dense extracellular matrix and high interstitial fluid pressure within solid tumors severely restrict the deep penetration of nanorobots, often limiting therapeutic effects to the tumor periphery

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