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Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols
Frequency: Once per day (subcutaneous), typically before bedtime
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Among them, their role as components of the general thiol/disulfide redox buffer, metal chelators, radical quenchers, substrates for specific redox reactions (GSH), and specific reductants of protein disulfide bonds (thioredoxin) can be highlighted (Wall et al., 2012)
NAD+ metabolism and cellular processes review
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