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1 Introduction Parkinsons disease (PD) is one of the most disabling diseases globally ( Type 2 diabetes mellitus (T2DM) is considered one of the risk factors for PD ( 2 Dopaminergic neurotransmission in PD pathogenesis The dopaminergic neurotransmission in PD pathogenesis involves the loss and apoptosis of dopaminergic neurons in the brain, as well as a reduction in dopamine levels, leading to an absolute deficiency of dopamine ( 3 PD pathogenesis and glucose metabolism and energy conversion disorders The pathogenesis of PD is linked to disturbances in glucose metabolism and energy conversion disorders

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