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Human CHAC1 protein degrades glutathione, and mRNA induction is regulated by the transcription factors ATF4 and ATF3 and a bipartite ATF/CRE regulatory element

GSH requires cysteine for replenishment, but the cysteine reserves have already been depleted in the sulfation of Tylenol metabolism

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In addition, knockdown of xCT exacerbates Ang II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice