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Once anesthetized, the right knee joints of the animals were shaved, sterilized, and subjected to an intra-articular injection of collagenase type II

They are commonly prescribed to: Manage type 2 diabetes by lowering blood sugar and reducing the risk of cardiovascular complications

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Risk factors include older age, autonomic neuropathy, polypharmacy (especially antihypertensives and diuretics), and volume depletion from gastrointestinal side effects

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