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Semaglutide, a selective GLP-1 receptor agonist, primarily acts on central appetite regulation and gastric emptying, leading to reduced caloric intake, improved satiety, and clinically meaningful reductions in glycated hemoglobin (1.31.6%) and body weight

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Mizgerd JP, Spieker MR, Doerschuk CM (2001) Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice

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