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SIRT3 protects cells from hypoxia via PGC-1- and MnSOD-dependent pathways
Phase separation was induced by addition of ice-cold water (150 l), followed by vortexing, incubation at 4 C (10 min) and centrifugation (1,000 g , 10 min, 4 C)
As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
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Everything below is a proposed mechanism with varying and generally weak support
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