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We demonstrate applicability beyond 5FU treatment in CRC to any TS-targeted therapeutics in other disease subtypes
(2016) The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells, Free Radic
doi: 10.1016/j.jacl.2021.05.007 268 WongCKMcLeanBABaggioLLKoehlerJAHammoudRRittigNet al
Who Should Avoid It Known copper sensitivity or Wilson's disease Active skin infections at application site Pregnancy or breastfeeding (injectable) Stop Right Away If You Notice Severe skin irritation, burning, or persistent redness Allergic reactions (rash, swelling, difficulty breathing) Unusual skin discoloration or staining Persistent metallic taste (injectable) Worsening of skin condition after 4-6 weeks Milder Signs to Watch For How Long Should a GHK-Cu Cycle Last
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