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Research has shown that variations in the OCT1 gene play a significant role in the varying effectiveness of metformin treatment for individuals with T2DM (Gambineri et al., 2010
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Bacterial contamination from unswabbed vial stoppers or non-sterile technique is another possibility
Semaglutide is not primarily renally excreted but is extensively metabolised with subsequent elimination of metabolites in urine and faeces
It is a suboptimal response that may still be clinically meaningful
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