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It was found that the use of inhibitors of ferroptosis could reduce cigarette smoke-induced cell death, suggesting that ferroptosis plays an important role in cigarette smoke-induced trophoblast cell death and may contribute to miscarriage ( 5 Pathophysiological mechanism 5.1 Molecular mechanisms of ferroptosis Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation and oxidative stress, playing a significant role in RM through trophoblast dysfunction

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Figure 3 Mice with functional loss mutations in the ALOX12B gene induced by ethylnitrosourea had red and shiny skin at birth, but quickly became dry and led to death, without exhibiting typical ichthyosis-like lesions (142)

[10] Additive depressant effects occur with other class I antiarrhythmics, phenytoin, and volatile anesthetics, while epinephrine-containing local formulations may potentiate vasoconstriction and delay systemic absorption-beneficial for prolonging local anesthesia but hazardous if inadvertent intravascular injection occurs