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In a randomized, double-blind, placebo-controlled trial, once-weekly exenatide (2 mg) administered for 48 weeks significantly improved motor scores in patients with PD, with benefits sustained even after treatment discontinuation ( Collectively, these findings indicate that incretin mimetics provide neuroprotection extending beyond metabolic regulation by targeting multiple pathogenic processes in PD, including mitochondrial dysfunction, neuroinflammation from oxidative stress, sirtuin dysregulation, insulin resistance, and S toxicity (Figure 2)
Patients with a history of significant sugar consumption may have established neural pathways that require more time to recalibrate
This is the single most important practical distinction, and it deserves to be stated without hedging
Journal of the American Academy of Child & Adolescent Psychiatry , 54(10), 899906
This relatively prolonged half-life is a key pharmacological characteristic of the molecule and has important implications for how the drug is administered and how it behaves within the body over time
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