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Several mechanisms have been implicated in the pathophysiology of diabetes-induced OA
While the weight loss itself often benefits the system, the impact of GLP-1s on reproductive hormones and cycle is a complex area, and it is imperative to use strict contraception and stop treatment immediately if attempting to conceive or upon becoming pregnant due to potential GLP-1 fertility concerns
As of June 2026, the market for GLP-1 tablets is more limited than GLP-1 injections, with only one option approved for treating obesity
If dosage and route of administration are correct, no side effects are occurred
Retatrutides ~24.2% (48 wk, 12 mg monotherapy) and cagrilintides ~10.8% (26 wk, 4.5 mg monotherapy) differ in duration and dose, and cagrilintides strongest data are combination (CagriSema) data
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