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In a glucose-deprived tumor microenvironment (TME), which is generally seen when nutrients are depleted, high level of lactate is converted into pyruvates (LDH-catalyzed reverse reaction) and then cancer cells can utilize pyruvate for the TCA cycle through the action of pyruvate kinase [81]

Food and Drug Administration (FDA) for the specific indications described

Clinical relevance : In research contexts, this experimental compound is utilized mainly to observe GH regulation, adipocyte metabolism, and the endocrine feedback loops

Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging

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