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The diuretic and natriuretic effects of GLP-1 are mediated through downregulation of sodiumhydrogen exchanger 3 (NHE3) activity in the renal proximal tubule that consequently affects renal hemodynamics [112]

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Tirzepatide is a dual GIP/GLP-1 receptor agonist that acts on both incretin pathways

Substantial Weight Reduction In a 48-week Phase 2 obesity trial, participants receiving retatrutide 12 mg once weekly reached an average 24.2% body weight reduction , with weight loss continuing through the study period rather than plateauing early