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At first the bodies of vegetarians and vegans did not produce much TMAO even when they took supplements, but after a few weeks they did, Hazens team reported in the Journal of Clinical Investigation . In Medical Express December 10, 2018 they reported, The findings suggest that measuring and targeting TMAO levelssomething doctors can do with a simple blood testmay be a promising new strategy for individualizing diets and helping to prevent heart disease

These have more obvious safety and efficacy data.