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The structure of the CYP51A1 protein contains multiple helices and -folds, forming a complex three-dimensional structure, which facilitates the binding of the protein to the substrate and the catalysis of the reaction [26, 27]

Compared with other forms of cell death, such as autophagy, apoptosis, and pyroptosis, ferroptosis exhibits distinct morphological, biochemical, and immunological characteristics (Xia et al., 2025)

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The absence of hepsin, as in hepsin / mice, resulted in increased APAP toxicity, leading to decreased overall survival and accelerated mortality