While the largest percentage of intracellular iron is tightly bound to or incorporated into proteins as a cofactor or for storage, small portion of intracellular iron resides in the cytosol and intracellular organelles (e.g., lysosomes) and constitutes a redox-active liable iron pool, which regulates programmed cell death including ferroptosis 42
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The relative copy numbers of mitochondrial to nuclear DNA were determined by real-time PCR with primers specific to cytochrome c oxidase subunit II (COX II) (mitochondrial) 5-ATCCCAGGCCGACTAAATCA (forward) and 5-TTTCAGAGCATTGGCCATAGAA (reverse) and -actin (nuclear) genes 5-TATCCACCTTCCAGCAGATGT (forward) and 5-AGCTCAGTAACAGTCCGCCTA (reverse)
Yan Z, Deng Y, Huang L, Zeng J, Wang D, Tong Z, et al
Women with endometriosis may have gastrointestinal symptoms such as bloating, IBS, constipation, and nausea