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The established ability of GLP-1RAs to suppress glial cell activation and modulate cytokine releasekey drivers of these very pathwayspositions them as a uniquely targeted therapeutic strategy
As a result, it improves A1C and supports meaningful weight loss
[1] [2] This accumulation occurs regardless of dose due to the long half-life of semaglutide
This would be equal to 0.8mg/daily for a 175lb individual [4]
Br J Pharmacol 179(4): 600624
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