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therefore, they probably represent the most suitable active comparator over the study period overall

As their use becomes increasingly widespread thanks to high-profile drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), questions about their long-term safety, efficacy and impact on body composition remain at the forefront

In the study by Lee et al , 4 biallelic inactivation of SUZ12 or EED was identified in 69% (34/49) of malignant peripheral nerve sheath tumors (epithelioid variant excluded), which is in accordance with the rate of H3K27me3 complete loss (72%) observed in our study

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