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While Ozempic, Mounjaro, Zepbound, and Wegovy are all GLP-1 agonists, Mounjaro and Zepbound are also considered glucose-dependent insulinotropic polypeptide (GIP) agonists

Reduced SCFA production means less GLP-1 stimulation from L-cells

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Diabetes-related thrombotic risk factors include: Hyperglycaemia-induced endothelial dysfunction , promoting a prothrombotic state Increased platelet reactivity and aggregation Elevated levels of clotting factors including fibrinogen and von Willebrand factor Chronic inflammation with raised inflammatory markers Impaired fibrinolysis , reducing the body's ability to break down clots Obesity independently increases thrombotic risk through multiple mechanisms

GLP-1 medications typically achieve this threshold within 8 to 12 weeks, though individual timelines vary