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It also explains why the final FDA response matters: the committee did not reach anything close to consensus, and FDAs own scientific review remained negative
Weeks 1-4: Initial Evaluation Period Treatment begins according to your providers instructions
Long-term effects have not been studied in humans or even in animals beyond short-term protocols
The researchers noted that a narrower definition would limit access to about 1 in 7 Medicare beneficiaries with an elevated BMI, while broader criteria could dramatically expand eligibility
Huang et al., 2025
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