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The molecule has to penetrate the stratum corneum (the skin's outer barrier) to reach the dermis where collagen is actually produced

Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis

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As a receptor tyrosine kinase, IGF-IR can activate a couple of tyrosine kinases that have important roles in tumor progression, such as Src, FAK, JAK, RON, and MET [56, 57]