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Medications and other Remedies for Constipation: Colace-OTC stool softener Dulcolax laxative OTC Senna OTC Magnesium can sometimes be helpful Lactulose (prescription) Linaclotide (prescription) Lubiprostone (prescription) Dietary modifications for constipation: Eating smaller, more frequent meals and avoiding high-fat foods can help minimize gastrointestinal discomfort