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This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences

The polyurea generation 4 (PURE G4 ) dendrimer was already explored as nanocarrier of several drugs by our group in the context of ovarian [26, 27], lung [28], and breast cancer [29] and even in the context of endothelial cells activation and cancer angiogenesis [29]

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Before a drug candidate can be administered to humans, it must be supported by years of scientific research, non-clinical investigation and quality assessment aimed at understanding its mechanism of action, safety profile and potential therapeutic value

Angiogenesis serves as a primary mechanism through which the compound facilitates the growth of capillaries