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Energy Expenditure and Thermogenesis GLP3s glucagon receptor activation specifically contributes to increased energy expenditure through multiple pathways[6]: Enhanced hepatic fatty acid oxidation and lipolysis Increased thermogenic activity in brown adipose tissue Upregulation of uncoupling protein expression Potential FGF21-mediated metabolic effects This thermogenic component distinguishes the blend from pure GLP-1 or amylin-based approaches, addressing both energy intake (via satiety) and energy expenditure simultaneously

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The study established the ~6-day half-life and confirmed once-weekly dosing feasibility

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The beneficial effect is obtained with caffeine consumption at doses of 3mg/kg body weight at least one hour prior to exercise and only if any other caffeine consumption is avoided for at least 24 hours prior to consumption of the product in habitual caffeine consumers