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In fact some such studies already exist (96)

Chapman LE, Darling AL, Brown JE (2016) Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: a systematic review and meta-analysis

10.1001/jamasurg.2023.2414 91 RocksonS

For people with inflammatory arthritis (e.g, Rheumatoid arthritis, Psoriatic Arthritis, Lupus), this risk is even higher because they experience more heart disease complications than the general population