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Semaglutide works by stimulating a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake
No completed human efficacy or safety trial
On/off cycling here is driven by caution, not by tolerance data: because there is no long-term human safety record, building in scheduled off periods is the conservative research default
intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention
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