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The major drawback preventing the commercial success of chemical synthesis of GGC is the number of steps involved due to the three reactive groups on L-glutamic acid and L-cysteine molecules, which must be masked to achieve the correct regioisomer
For example, linagliptin and the novel DPP-4 inhibitor, BI 14361 have been shown to significantly reduce infarct size and myocardial fibrosis in an experimental model of myocardial ischemiareperfusion injury in Wistar rats [38]
These results were validated in the Food and Drug Administration Adverse Event Reporting System database (OR 0.72
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( : ) [ ] GLP-1
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