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For prescription availability in Canada right now: Tirzepatide is the closest alternative with strong efficacy (20.9%) and an existing prescription pathway
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Someone could use tirzepatide during the active weight loss phase, achieving the maximum possible weight reduction with the dual-receptor mechanism, and then transition to orforglipron for long-term maintenance
Taking these medications without being medically supervised can result in a lot of those side effects, Shah said
Funding These trials and costs relating to the development and publication of this manuscript were funded by Novo Nordisk A/S, Sborg, Denmark
