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waste clearance is the other
In many experimental animal models, MTX has been found to increase serum urea and creatinine levels (Reference Moodi, Hosseini and Abedini16,Reference Tousson, Zaki and Abu-Shaeir50,Reference Jafaripour, Naserzadeh and Alizamani51) , but there are also studies showing that MTX reduces serum urea concentration (Reference Budancamanak, Kanter and Demirel52Reference Severin, Campagno and Brandoni54)
Consistent with reports in other cancer types showing that GPX2 overexpression promotes cisplatin resistance by suppressing ROS accumulation, our findings suggest that NAC-associated upregulation of GPX2 may enhance intracellular antioxidant defenses, thereby promoting survival of residual tumor cells and contributing to chemoresistance [21, 22]
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Iron addiction: a novel therapeutic target in ovarian cancer
