However, enhanced expression of GGT and MRP1, which are associated with the -glutamyl cycle, has been observed in damaged myocardium [33, 34, 51, 52]
As aforementioned, PARPs govern the genome stability and gene transcription via NAD + -dependent ADP-ribosylation
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This dual regulation of transporters, by protein quality control and metabolic sensing, allows for modulation of mitochondrial glutathione levels in response to iron homeostasis, providing avenues for exploring the regulation of metabolic compartmentalization [24]