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Simultaneous use may reduce the effectiveness of both and elevate sensitivity

But the important question that remains unresolved is: what happens first after chemotherapy administration

Moreover, advanced light-dark schedules in genetically predisposed mice (e.g., K-ras/p53 mutants) led to enhanced tumor growth and cell proliferation with increased oncogene c-Myc expression, while clock gene knockouts have tumor suppressive effects 203

Learn more in the Patient Info Sheet below and in these videos featuring Brigitte Widemann, MD, who was the principal investigator of the selumetinib clinical trial at the National Institutes of Health