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Several studies that have investigated the effect of GZLFW on leiomyoma cells found that GZLFW is able to reduce cell proliferation and viability in a dose-dependent manner (Shen et al., 2016
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2020), with the CHARMM biomolecular force field and the TIP3P water model (Huang and MacKerell Jr 2013)
The challenges for using ACPs in cancer therapy are the poor bioavailability, immune response to treatments, toxicity of the peptides, and the cost-inefficiency of the approaches
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