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Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschop MH

The peptide's effectiveness when given either continuously (daily) or intermittently (4 applications over 10 days) suggests sustained biological effects beyond the peptide's short plasma half-life

Most headaches resolve within the first 2-4 weeks at any given dose level

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This study was inclusive of participants who had a history of psychiatric diseases