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Published online April 16, 2024
RNA-seq analysis revealed that DEGs between 0 mg/kg and 2 mg/kg anwuligan-treated mice were significantly enriched in several key pathways, including metabolic pathways, protein digestion and absorption, retinol metabolism, MAPK signaling pathway, PI3KAkt signaling pathway, Wnt signaling pathway, PPAR signaling pathway, BMP signaling pathway, and TGF-beta signaling pathway
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Hence, although future kinetic studies might confirm a random mechanism for the rate-limiting first part of monothiol mechanism (iii) in vitro, GSH is probably the first and the non-glutathione disulfide the second substrate under physiological conditions in vivo (Fig
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