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In addition, the following additional adverse effects may manifest if a dose larger than 5 grams is administered: Nausea Skin rashes, hives, or allergic reactions Diarrhea Liver, renal, and nerve system toxic effects
Jung S et al
HIF-1 overexpression or HO-1 agonist treatment suppresses TECs apoptosis by preventing hyperglycemia-induced mitochondrial membrane potential loss and mitochondrial fragmentation to eliminate tubular injury in DKD (108)
In: 4th International Congress of the GRS and the IGF Society
Zepbound (semaglutide) and tirzepatide both trigger this effect because they bind to GLP-1 receptors on stomach muscles
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