Exposure of RAW 264.7 cells to LPS for four hours dramatically increased the secretion of IL-6 to 613.2 35.1 pg/ml and TNF- to 1556.3 23.3 pg/ml
These clear effects (observed through comparison with various comparators, including current weekly GLP1-RAs on the market) are complemented by interesting data on cardiovascular safety and efficacy (from post-hoc studies) regarding the incidence and progression of nephropathy and hepatic steatosis
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Similarly, kojic acid can cause side effects such as erythema, stinging, moderate exfoliation, and contact dermatitis 25,26
Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC