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Loss of Plin2 activity results in reduced energy intake and increased physical activity in response to a high-fat diet indicating that Plin2 likely contributes to diet-induced obesity, adipose tissue inflammation, and the development of hepatic steatosis
& Hirao, I
Peptide combinations (stacking) for allergies are supported by mechanistic rationale and clinical reports but lack formal comparative trials
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The complex duality of CHAC1 in oncology, acting as both a tumor suppressor by promoting ferroptosis and a potential oncogene in TP53 -mutant backgrounds, alongside its functions in neuroprotection and immunity, underscores its therapeutic potential
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