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Finally, the gastric protein Intrinsic Factor plays an essential role in the absorption of Vitamin B12 into the body
Beginning at 2.5 mg may reduce side effects such as nausea or stomach discomfort before increasing the dose
However, pharmacokinetic studies have shown methylcobalamin stays longer in brain and liver tissues
Target engagement remains context dependent, and metabolic mediation would require direct testing in adipocytes, adipose tissue, and whole-body metabolic models
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