Looking ahead, several key directions may accelerate the transition of ferroptosis research from basic science to clinical translation in AD: Construction of a dynamic, spatiotemporal ferroptosis atlas through integrated multi-omics profiling to define pathological staging and regional specificity
Immunohistochemical analysis displayed that metformin did not reduce MMP13 expression and only partially decreased ADAMTS5 levels, and Collagen II in Nrf2 KO mice were not significantly influenced by metformin treatment (Fig
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