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Supplemental CoQ10 is available in both forms, with some formulations of ubiquinol showing higher bioavailability in certain studies, though the clinical significance of this difference remains uncertain

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A larger clinical trial showed improvement in cognition ( ADAS-Cog12 ) in a subgroup of patients and improved AD biomarkers [95], and a subsequent analysis of CSF fluid showed reduced inflammation biomarker levels in the drug group [96]

ICER did have concerns that there was a lack of minorities represented in clinical trials