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Initially, ischemia causes ATP depletion, anaerobic metabolism, and intracellular acidosis, resulting in impaired ion pumps and calcium overload 1,2,3
In the livers of patients with Wilson disease, as well as in corresponding animal models, both copper accumulation leading to cuproptosis and iron overload causing ferroptosis have been well documented
Lateral tongue laceration
As expected, FAPP1-PH showed a strong binding to the spot containing PI4P (Supplementary Fig