soul trial oral semaglutide cardiovascular outcomes 2024 2025 Updates in Medicine on X: "SOUL (NEJM 2025): led to a 14% ↓ in major CV events vs placebo in T2DM with ASCVD or CKD — no ↑ in Frontiers | Cardiovascular Safety and

The challenge is that GLP-1s for type 2 diabetes are often prescribed as a last resort, only after other treatments have failed or complications have developed

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The mechanical unloading of joints and reduction in systemic inflammation associated with weight loss may account for the observed improvements

Proper hydration is essential for nutrient transport

Tirzepatide side effects are often most noticeable: during the first days or weeks of treatment in the days after a dose increase when restarting treatment after a break Most people start at 2.5 mg once a week, and the dose goes up in steps of 2.5 mg no sooner than every 4 weeks