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Two things are worth keeping in mind: this was shown in mice and laboratory cells, not yet in humans, and it is a different pathway from the fiber-and-SCFA route below

Feb 2021;55:101385

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Unlike the previous concept, that melanomas develop de novo intra-orally, it can be hypothesized that melanomas are preceded by oral melanotic macules or melano-acanthoma, having melanocytic hyperplasia and/or dysplasia instead of having the same number of typical melanocytes with an increased tendency to synthesize melanin pigment

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