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2023: Tirezepatide (Zepbound) receives FDA approval for weight loss

Before we dive into protocols, lets establish a clear baseline

To keep the model practical, we focus on a short list of inputs that move the market the most, such as type 2 diabetes and obesity prevalence trends, share of eligible patients who initiate GLP-1 therapy, persistence and discontinuation behavior, the split between diabetes and weight management demand, and the net price direction after rebates and coverage decisions