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Combination and Small Molecule GLP-1 Drugs The number of main pipelines is even smaller for small-molecule GLP-1 drugs and GLP-1 combination drugs
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Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway
Semaglutide does cause a small increase in resting heart rate (24 beats per minute on average), which should be monitored but rarely requires intervention
At baseline, mean age was 47 years (range 18 to 80), 74% were female, 86% were White, 4% were Asian and 9% were Black or African American
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