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An experimental model of GLP-1R knockout mice (GLP-1R-/-) [37] demonstrated that (GLP-1R-/-) mice exhibited only modest decreases in gonadal weight, while females exhibited delayed puberty, but subsequent fertility and sex-steroid secretion were normal
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This was not merely a cosmetic side effect but a potentially therapeutic benefit, given that obesity underlies much of type 2 diabetes
Images were acquired 24 48 h later, on a Keyence BZ-X800 microscope using negative control sections to adjust for background fluorescence
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